Body Surface Area in Dosing Anticancer Agents: Scratch the Surface!
نویسندگان
چکیده
منابع مشابه
Body surface area in dosing anticancer agents: scratch the surface!
Grochow et al. (1) questioned the use of body surface area in dose normalization more than a decade ago in this Journal. In this issue, Baker et al. (2) retrospectively assessed the pharmacokinetics of 33 investigational agents tested in phase I trials during the past decade as a function of body surface area in 1650 adult cancer patients. Based on their findings, they recommend that the practi...
متن کاملFlat-fixed dosing versus body surface area based dosing of anticancer drugs: there is a difference.
In a recent review, Mathijssen et al. [1] proposed using flatfixed dosing regimens rather than body surface area (BSA)based dosing for anticancer drugs because “it does not seem worse than using BSA-based dosing” with regard to pharmacokinetic variability. We feel that this statement, together with other recent publications arguing against BSAbased dosing, requires a counterpart. Most cytotoxic...
متن کاملStandardization of the body surface area (BSA) formula to calculate the dose of anticancer agents in Japan.
BACKGROUND The importance of deciding the appropriate dose of anticancer agents cannot be overemphasized. Body surface area (BSA) has been used to calculate the dose in anticancer therapy since the 1950s. Japanese oncologists, often use their own Japanese BSA formula instead of western BSA formulae. However, it is not widely known that some discrepancies exist between the BSA products of the Ja...
متن کاملUnexpected toxicity associated with use of body surface area for dosing melphalan in the dog.
A multiinstitutional Phase I study using i.v. melphalan was conducted in dogs with spontaneously occurring neoplasia. Melphalan was administered at 7.5, 10, 11.25, 12.5, and 20 mg/m2 of body surface area. Disproportionately greater toxicity was observed in small dogs. Seven of the eight dogs (88%) weighing less than 14 kg experienced severe myelosuppression (neutropenia, less than 1500/mm3; and...
متن کاملDetermination of Body Surface Area Surface Area Using the and Formulas to Estimate Body Alginate Method
The purpose of this study was to determine thc body surface arca (BSA) based on the alginate method to derive fbrmulae for estirnating BSA, and to compare the error of the present fbnnula to prcvious forrnulas obtained from other countries, We directly measured thc entire body surfacc area of 34 males (20-60 years old, l58,5-187.5 cm in height, 48.5-103.1 kg in body weight) and 31 females (20-6...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2002
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/94.24.1822